Cure Childhood Cancer

Current Research Initiatives

Dr. Kelly GoldsmithAnd the research continues. This fiscal year we are allocating $2.5 million in Pediatric Research Grants and Fellowships to support scientists at:

  • The Aflac Cancer Center and Blood Disorders Center of Children’s Healthcare of Atlanta
  • Emory University
  • Children’s Hospital of Philadelphia
  • Seattle Children’s Hospital
  • Children’s Cancer Therapy Development Institute
  • Memorial Sloan Kettering Cancer Center

For fiscal year 2015-2016, CURE is supporting 19 specific projects, most of which focused on finding effective treatments for the 20% of kids who do not survive childhood cancer.

Aflac Cancer and Blood Disorders Center at Children’s Healthcare of Atlanta/Emory:
1. Anna Kenney, PhD for the proposal entitled YAP-mediated metabolism and mitochondrial morphology in Medulloblastoma

2. Cynthia Wetmore, MD, PhD for the Phase I study of Abemaciclib (Cdk 4/6 inhibitor) in children with newly diagnosed diffuse intrinsic pontine glimoa and in recurrent solid tumors including malignant brain tumors

3. Ann Mertens, PhD for proposal entitled Nurse Navigators as a Strategy to Engage Childhood Cancer Survivors in Follow-up Care

4. Jordan Gilleland Marchak, PhD ABPP for the proposal entitled Evaluating Patient Engagement in Survivor-focused Healthcare after Childhood Cancer Treatment;

5. Kevin Bunting, PhD for the proposal entitled Leukemia-Selective STAT5 Inhibition in High Risk Acute Myeloid Leukemia

6. Kelly Goldsmith, MD for the proposal entitled Targeting epigenetic regulation of COUP-TF1 to restore therapy response in high-risk neuroblastoma

7. Tobey MacDonald, MD for the proposal entitled STAT3 Inhibitor WP1066 as a Novel Therapeutic for Medulloblastoma

8. Erwin Van Meir, PhD for the proposal entitled Targeting MBD2-mediated BAl1 silencing for Medulloblastoma treatment

9. Melinda Pauly, MD for year two of the Phase I Study of Dasatinib in Combination with Chemotherapy for Relapsed or Refractory Core Binding Factor Acute Myeloid Leukemia

10. Muna Qayed, MD for year two of the Phase I Study of Mesenchymal Stromal Cells for the Treatment of Acute and Chronic Graft versus Host Disease

11. Two fellows and fellowship endowment

Memorial Sloan Kettering Cancer Center:
12. Richard Phillips MD PhD / C. David Allis PhD (COHPI) for the proposal entitled Mechanisms of oncogenesis in histone mutant pediatric glioma;

13. Dr.’s Daria Valerio and Scott Armstrong for year two of the proposal entitled Combinatorial Targeting of Epigenetic Mechanisms in MLL-rearranged Acute Leukemia.

Children’s Hospital of Philadelphia:
14. Margaret M. Chou, Ph.D. for the proposal entitled Epigenetic Mechanisms underlying Ewing Sarcoma Pathogenesis

15. Garrett M. Brodeur, MD for the proposal entitled Nanoparticle-Encapsulated Tyrosine Kinase Inhibitors to Treat Neuroblastomas

16. Richard Aplenc, MD for year two of the proposal entitled Evaluating Mitochondrial DNA and the role of its variation in the risk of relapse and toxicity in children with AML

17. Michael Hogarty, MD for year two of the proposal entitled Therapy Resistance in Neuroblastoma.

Children’s Cancer Therapy Development Institute:
18. Dr. Charles Keller for the proposal entitled “CUREfast: Accelerating Research with Families;” Cancer Registry for Familial and Sporadic Tumors

Seattle Children’s Hospital:
19. Dr. Leslie Kean for Phase 2 clinical trial of Abatacept.

 

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